Description
Product Characteristics:
Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.
Subcellular location: Cell membrane
Synonyms: CD355, Cytotoxic and regulatory T-cell molecule, Class-I MHC-restricted T-cell-associated molecule, CRTAM
Target Information: The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A\, MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]